To me, it is incomprehensible that nature would work so very hard to actively bring an alleged “killer substance, a toxin, a poison, e.g., (ground state triplet diradical oxygen, O2)” into its midst but it would logically do so to sustain itself with the life rendering energy potential possessed of oxygen. With billions of years to perfect aerobic metabolism, I remain highly circumspect that the generation of superoxide or hydrogen peroxide from one of every 20 processed oxygen molecules, which passes through the electron transport chain en route to oxidative phosphorylation, is the result of a “leak” or a colossal design flaw. The production of electronically modified oxygen derivatives (EMODs, formerly called reactive oxygen species or oxygen free radicals) is essential to the life process in humanoid obligate aerobes and to all aerobic life forms. Without these EMODs, we would die summarily. My book presents in depth scientific research into the crucial role of oxygen in our daily lives and shows it is the basis of healthy homeostasis. It is for the medical scientist and informed layman. U.T.O.P.I.A. (Unified Theory of Oxygen Participation In Aerobiosis) is the compelling discussion of ground state oxygen, O2, its reactive oxygen and nitrogen species (RONS) (electronically modified oxygen derivatives, EMODs) and its primary electronic excitation state, (metastable singlet delta oxygen), as a crucial, stately component of all aerobic life. Countless attempts using antioxidants to remedy problems associated with over 100 disease states and to stall aging have failed. They have failed because the free radical theory is obviously wrong. Had the theory been correct, we would be living disease-free for life spans approaching that of Methuselah (969 years); but, none of this has come to pass. The conundrum of aging and disease will not be solved by trying to pin the blame for all-things-bad on oxygen. In fact, attempts to do so have terribly complicated this scope of scientific investigation.